[NMusers] Cross-validation script in NM

From: Pieter Colin <Pieter.Colin_at_UGent.be>
Date: Thu, 4 Dec 2014 18:03:59 +0100

Dear nm-users,

I'm trying to construct a NONMEM control file to be used in a cross-validat=
ion study.
In a first problem statement I run an estimation step on a subset of my dat=
In a subsequent problem statement (within the same control file) I am tryin=
g to predict the PK of the subset that was not included in part 1.

I managed to do this by use of the MSFO option (in the first part of the co=
ntrol file) and the $MSFI in de second part.
However, it appears that time-varying covariates (defined under $PK in the =
first problem statement) are not evaluated when performing the predictions =
for the second problem statement.

Does anyone know of a workaround for this or is there another way of combin=
ing a fit and predict action (both on different data) within the same contr=

Kind regards,


Pieter Colin, Pharm.D., Ph.D.

Post-Doctoral researcher
(Faculty of Pharmaceutical Sciences - Ghent University)
Associate Professor
(Department of Anesthesiology - UMCG)

Received on Thu Dec 04 2014 - 12:03:59 EST

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