[NMusers] PK/PD Modeling Job Opportunities at Johnson & Johnson

From: Hu, Chuanpu [JRDUS] <CHu25_at_its.jnj.com>
Date: Wed, 3 Dec 2014 15:40:32 +0000

Scientific Director - PK/PD Modeling Job at Johnson & Johnson (8896141109)
Date: Dec 03, 2014
Location: Spring House, PA, US

Description

Janssen Research & Development, L.L.C., a Johnson & Johnson company, is rec=
ruiting a Scientific Director of PK/PD Modeling to be located in Spring Hou=
se, PA. Additional positions are also available commensurate to experience.

Janssen Research & Development, L.L.C. develops treatments that improve the=
 health and lifestyles of people worldwide. Research and development areas =
encompass novel targets in neurologic disorders, gastroenterology, oncology=
, infectious disease, diabetes, hematology, metabolic disorders, immunologi=
c disorders, and reproductive medicine.

Janssen Pharmaceuticals, Inc., a pharmaceutical company of Johnson & Johnso=
n, provides medicines for an array of health concerns in several therapeuti=
c areas, including: attention deficit hyperactivity disorder (ADHD), cardio=
vascular disease, general medicine (acid reflux disease, infectious disease=
s), mental health (bipolar I disorder, schizophrenia), neurologics (Alzheim=
er's disease, epilepsy, migraine prevention and treatment), pain management=
, and women's health. Our ultimate goal is to help people live healthy live=
s. We have produced and marketed many first-in-class prescription medicatio=
ns and are poised to serve the broad needs of the healthcare market - from =
patients to practitioners, from clinics to hospitals. For more about Jansse=
n Pharmaceuticals, Inc., one of the Pharmaceutical Companies of Johnson & J=
ohnson, visit http://www.janssenpharmaceuticalsinc.com/
Thriving on a diverse company culture, celebrating the uniqueness of our em=
ployees and committed to inclusion. Proud to be an equal opportunity employ=
er.

The Scientific Director will conduct advanced PK/PD modeling research with =
emphasis on disease progression modeling and implementation of mechanism-ba=
sed approaches. Will support product development as Model Based Drug Develo=
pment (MBDD) Leader by defining the dose-concentration-pharmacological effe=
ct relationships of drugs using modeling and simulation methodologies from =
data acquired at various stages of drug research and development. Perform b=
asic and clinical disease research, with a focus on CNS, Immunology, and/or=
 Oncology compounds. Perform population PK and PK/PD analysis for regulator=
y submissions. The successful candidate uses state-of-the-art computer mode=
ling and simulation techniques to formulate various clinical trial design s=
cenarios and outcome analyses. Will have full technical responsibility for =
interpreting, organizing, executing, and coordinating assignments. Conceptu=
alize plan, develop and execute R&D projects that have a major impact on ke=
y development programs, and acts as the MBDD representative on Clinical and=
/or Compound Development Teams. Actively maintain relationships and collabo=
rate with colleagues within or outside the MBDD organization and J&J at lar=
ge. Part of the Scientific Director's time will need to be devoted at estab=
lishing and maintaining external collaborations with Academic groups active=
 in CNS, Immunology, and/or Oncology worldwide. Will be responsible for act=
ing independently on scientific and technical matters pertaining to his/her=
 field, to drive advancing the science in the field, to identify research o=
pportunities and to coordinate them. The successful candidate will serve as=
 senior technical expert for the organization in the application of advance=
d PK/PD and disease modeling principles, as well as in mechanism-based conc=
epts and processes.

Qualifications


A minimum of a Master's degree in Pharmaceutical Sciences, Clinical Pharmac=
ology, Chemical/Biomedical Engineering or related discipline with a minimum=
 of 10 years of pharmaceutical development experience in various aspects of=
 modeling and simulation is required OR a Ph.D. in Pharmaceutical Sciences,=
 Clinical Pharmacology, Chemical/Biomedical Engineering or related discipli=
ne with a minimum of 8~10 years of pharmaceutical development experience in=
 various aspects of modeling and simulation is preferred.

Hands-on experiences with population approach in describing PK/PD systems w=
ith various types of clinical pharmacology data is required. Demonstrated e=
xperience identifying research projects and successfully managing them in c=
ollaboration with internal or external teams is required. In-depth knowledg=
e of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD model=
ing principles and statistics is required. Experience with NONMEM, R and/or=
 other modeling and simulation software is required. Thorough knowledge of =
planning, conducting, evaluating and reporting PK/PD studies in R&D is requ=
ired. The ability to perform basic and clinical disease research, with a fo=
cus on Oncology, Immunology and/or Infectious Diseases compounds is preferr=
ed. Excellent communication and interpersonal skills is required. Experienc=
e with biologics drug development is preferred. Experience working with cro=
ss functional teams is preferred.

Johnson & Johnson companies are equal opportunity employers.
To apply, please visit http://careers.jnj.com/full-time-opportunities and e=
nter job number: 8896141109


Honghui Zhou, PhD, FCP
US Head, Pharmacological and Translational Modeling
Model-Based Drug Development
[Janssen_Hor_RGB]
Janssen Research & Development, LLC
Welsh & McKean Roads
P.O. Box 776
Spring House PA 19477
Tel: + 1 215.793.7261 Fax: +1 215.986.1013
hzhou2_at_its.jnj.com<mailto:dclymer_at_its.jnj.com>



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Received on Wed Dec 03 2014 - 10:40:32 EST

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